Botox vs. Dysport vs. Xeomin: Which is best for treating wrinkles?

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Aging, genetics, and lifestyle factors can leave our skin looking less than its best. One way people choose to combat these signs of bodily change is to seek out medical treatments such as injectables. We are probably all familiar with Botox, but let’s look deeper into neuromodulators as a whole.

What Are Neuromodulators?

All three of these injectables are in a class of chemicals known as neuromodulators. Neuromodulators act to excite or inhibit the activity in receptors.

The three we are discussing are all derived from botulinum toxin type A. These particular neuromodulators work in the body by preventing the release of acetylcholine by binding to certain receptors. When acetylcholine isn’t present, there is lack of communication between muscles and the nervous system. This will allow a relaxing or paralysis effect on the muscles.

Neuromodulators such as these have a wide array of uses in medicine. They have been used to treat conditions such as:

  • Urinary incontinence
  • Excess sweating
  • Migraines
  • Twitching eye muscles
  • Tight jaw muscles

They are also wonderful for cosmetic reasons. They help deal with fine lines and wrinkles, crows feet, and laugh lines.


Year Approved: Botox was FDA approval in 1989.
Manufacturer: Botox is manufactured by Allergan.

Botox is the pioneer in neuromodulators available to the public. It was the first of the three to come out and set the stage. It’s a household name and has been proven to give results for decades. People feel comfortable using it and consider it reliable. Botox differs from the other products because it contains a protein they don’t. This protein separates from the toxin after injection, but it causes no discernible difference in efficacy.


Year Approved: Dysport was granted FDA approval in 2009.
Manufacturer: Dysport is manufactured by Medicis.

Dysport came about next. The difference here lies in the dilution process while making it. Dysport costs less than Botox. However, due to its manufacturing process, you may need a larger quantity. The smaller molecules in this formula allow for faster results, but can also enable spreading to larger areas.


Year Approved: Xeomin was granted FDA approval in 2001.
Manufacturer: Xeomin is manufactured by Merz.

Xeomin is the latest neuromodulator addition. It isn’t formulated with the extra proteins that Botox has. This manufacturing process allows Xeomin to be unrefrigerated. This effects storage and distribution, but not efficacy. This formula does take longer than the others to show results. Dysport’s results take 24 hours, Botox results take 72 hours, and Xeomin’s results take 4 days.

Despite time and manufacturing differences, all three are similar when it comes to results, longevity, and risk of side effects. In the end, choosing between these products tends to be up to personal preference.

If you’d like to experience great anti-aging results for yourself, call Dr. Steven Wallach and his staff today to book a consultation.

Steven Wallach MD

Steven Wallach MD

Dr. Wallach is a board-certified plastic surgeon in New York City who specializes in performing cosmetic procedures of the face, breast and body. As one of the cutting edge experts in the field, Dr. Wallach consults on a regular basis with people in the beauty, media, and publishing worlds.

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